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    婦女圍生期抑郁癥與雌二醇水平關系的觀察

    來源:用戶上傳      作者:錢宏威 鄭琳

      摘 要 目的:^察婦女圍生期抑郁癥狀發生的時間節點以及抑郁癥狀與雌二醇(estradiol,E2)的相關性。方法:納入2019年1月―2020年12月建卡的懷孕婦女200名,在孕早期、孕晚期、產后1個月時評估其一般情況和情緒變化,觀察E2在孕產婦不同時間段的波動及與愛丁堡孕產期抑郁自評量表(Edinburgh postnatal depression scale,EPDS)得分之間的關系。結果:發生在孕早期、孕晚期和產后1個月時的可能抑郁癥人數分別為20例(10.0%)、43例(21.5%)和64例(32.0%),發生明確抑郁癥人數在孕早期時有3例(1.5%)、孕晚期時7例(3.5%)、產后1個月時13例(6.5%),均隨著時間逐漸增加。在孕早期時EPDS得分平均為(5.31±2.04)分、孕晚期時為(9.44±3.33)分、產后1個月時為(12.06±4.09)分,隨著時間逐漸升高,產后1個月時最高。孕早期時E2值平均為(233.67±80.05)ng/L、孕晚期時為(1609.11±702.78)ng/L、產后1個月時為(109.22±40.33)ng/L,E2水平先升高后降低,在孕晚期達到最高峰。在孕早期、孕晚期時EPDS得分與E2水平不存在相關性,在產后1個月時兩者呈正相關,相關系數為0.679(P<0.001),即圍生期婦女的EPDS得分越高其E2水平越高。結論:婦女圍生期抑郁癥狀發生的時間節點介于孕晚期與產后1個月之間,產后1個月時抑郁癥狀與E2水平存在中度正相關性。
      關鍵詞 圍生期;抑郁癥;雌二醇
      中圖分類號:R714.7 文獻標志碼:A 文章編號:1006-1533(2022)14-0018-03
      引用本文 錢宏威, 鄭琳. 婦女圍生期抑郁癥與雌二醇水平關系的觀察[J]. 上海醫藥, 2022, 43(14): 18-20, 36.
      Observation of relationship between perinatal depression and estradiol level in women
      QIAN Hongwei, ZHENG Lin
      (General Practice Department of Shihua Community Health Service Center of Jinshan District, Shanghai 201540, China)
      ABSTRACT Objective: To observe the time node of depressive symptoms in women during perinatal period, and the correlation between depressive symptoms and estradiol(E2). Methods: Two hundred pregnant women who established cards from January 2019 to December 2020 were included, the general condition and mood changes were assessed in the first trimester, third trimester, and 1 month postpartum, and to observe the fluctuation of E2 in different time periods of pregnant women and its relationship with Edinburgh postnatal depression scale(EPDS) score. Results: The numbers of possible depression occurred in the first trimester, third trimester, and 1 month postpartum were 20 cases(10.0%), 43 cases(21.5%) and 64 cases(32.0%), respectively, and the numbers of definite depression cases occurred in 3 cases(1.5%) in the first trimester, 7 cases(3.5%) in the third trimester, and 13 cases(6.5%) at 1 month postpartum, all of which gradually increased with time. The average score of EPDS in the first trimester was (5.31±2.04), in the third trimester was (9.44±3.33) and at 1 month postpartum was (12.06 ± 4.09), and gradually increased with time, the highest was at 1 month postpartum. The average E2 value was (233.67±80.05) ng/L in the first trimester,(1 609.11±702.78) ng/L in the third trimester, and (109.22±40.33) ng/L at 1 month postpartum. The level of E2 increased first and then decreased, and reached the peak in the third trimester of pregnancy. There was no correlation between EPDS score and E2 level in the first trimester, third trimester, there was a positive correlation between them at 1 month postpartum, and the correlation coefficient was 0.679(P<0.001), that is, the higher the EPDS score of perinatal women, the higher the E2 level. Conclusion: The time node of perinatal depressive symptoms in women is between the third trimester and one month postpartum, and there was a moderate positive correlation between depressive symptoms and E2 levels at 1 month postpartum.

    nlc202208181532



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